PRODUCTION OF AN ANTICARCINOGENIC PROTEASE INHIBITOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16422
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2100 Maury Street P O Box 70, Des Moines, IA, 50301
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Nelson, Christopher E
 Principal Investigator
 (515) 266-2111
Business Contact
 1 R43 CA54685-01
Phone: () -
Research Institution
N/A
Abstract
TOMATO PLANTS, STABLY TRANSFORMED WITH A FUSED CAMV TOMATO INHIBITOR GENE LICENSED TO KEMIN INDUSTRIES, INC., FROM WASHINGTON STATE UNIVERSITY, WILL BE SCREENED FOR INDIVIDUAL LINES THAT PRODUCE VERY HIGH QUANTITIES OF ANTICARCINOGENIC PROTEASE INHIBITOR I IN THE UNRIPE FRUIT. HIGH YIELDING TRANSFORMANTS WILL BE CROSSED INTO COMMERCIALLY GROWN STRAINS. FRUITS FROM TRANSGENIC PLANTS POSSESSING HIGH LEVELS OF THE INHIBITOR WILL BE USED TO DESIGN AN ECONOMICALLY FEASIBLE PROCEDURE TO PROVIDE LOW COST INHIBITOR I FOR FURTHER STUDY IN ITS ROLE AS AN ANTICARCINOGENIC SUBSTANCE. IF LONG RANGE STUDIES DEMONSTRATE THE VALUE OF THE MATERIAL IN PREVENTING CANCER, PILOT AND, FINALLY, FULL SCALE PREPARATION PROCEDURES WILL BE UTILIZED TO PROVIDE PRODUCT TO THE MARKET. ACHIEVEMENT OF PHASE I OF THIS PROJECT SHOULD DEMONSTRATE A SCHEME IN WHICH THE ANTICARCINOGENIC PROTEASE INHIBITOR I CAN BE PRODUCED AT COSTS 5-10 TIMES LOWER THAN COMMERCIALLY AVAILABLE PRODUCT. PHASE II OF THE PROJECT WILL MOVE THE PREPARATION OF THE INHIBITOR INTO A DEMONSTRABLE PILOT PHASE AND WILL ALSO BE USED TO CREATE OTHER TRANSGENIC TOMATO PLANTS CONTAINING OTHER INHIBITORS. IT IS ANTICIPATED THAT THE PRODUCTION OF AT LEAST SOME OF THESE WILL BE MOVED TO PILOT SCALE IN PHASE II.

* Information listed above is at the time of submission. *

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