CONTROLLED IONTOPHORETIC DELIVERY OF NARCOTICS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7367
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Jmw Acquisition Company Inc
1290 West 2320 South Suite A, Salt Lake City, UT, 84119
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 TOMASZ J PETELENZ
 (801) 975-1191
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE AIM OF THIS PROPOSAL IS TO INVESTIGATE AND DEVELOP LONG-TERM IONTOPHORETIC PROCEDURES FOR DELIVERY OF NARCOTIC AGENTS. IONTOPHORESIS HAS BEEN KNOWN FOR A LONG TIME, BUT ITS APPLICATION IS LIMITED TO SHORT-TERM PROCEDURES (15 TO 30 MINUTES). THE MAJOR IMPEDIMENT TO LONG-TERM USE IS THE FORMATION OF ELECTROLYTIC PRODUCTS AT THE ELECTRODE, LOWERING THE EFFICIENCY OF DRUG TRANSPORT AND CAUSING BURNS. THESE PROBLEMS HAVE BEEN ADDRESSED AND LONG-TERM DELIVERY HAS BEEN STUDIED BOTH THEORETICALLY AND EXPERIMENTALLY WITH MORPHINE AS A MODEL DRUG. AS A RESULT, TREATMENT TIMES HAVE BEEN EXTENDED UP TO 2 HOURS WITH SIGNIFICANT MORPHINE LEVELS IN BLOOD AND NO COMPLICATIONS. THE PROPOSED STUDY INVOLVES (1) LABORATORY IN VITRO DETERMINATIONS OF IONTOPHORETIC ELECTRODE EFFICIENCY AND DELIVERY RATES OVER LONG (12 TO 24 HOURS) APPLICATION TIMES USING AN AUTOMATED, COMPUTER-CONTROLLED SAMPLING SYSTEM; (2) ANIMAL EXPERIMENTS USING NUDE RATS WITH ISOLATED SKIN FLAPS IN ORDER TO DETERMINE LONG-TERM DELIVERY RATES WITH (14)C MORPHINE HC1; AND (3) A CONTROLLED, DOUBLE-BLIND CLINICAL STUDY INVOLVING PATIENTS AFFLICTED BY SEVERE POSTOPERATIVE PAIN. THE RESULT OF THESE STUDIES WILL BE A NEW IONTOPHORETIC DRUG DELIVERY SYSTEM FOR NARCOTIC ANALGESICS, PRIMARILY MORPHINE. IN PHASE II, NEW ELECTRODE FORMULATIONS AND AN IONTOPHORETICCONTROL DEVICE WILL BE DESIGNED, FABRICATED, AND USED IN LARGE-SCALE, LONG-TERM CLINICAL TRIALS.

* information listed above is at the time of submission.

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