PULSE SIGNALS TO CELLS USING A UNIQUE PERIFUSION SYSTEM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$460,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
1491
Agency Tracking Number:
1491
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Kms Fusion (Currently Kms Fusion Inc)
3621 South State Road, Ann Arbor, MI, 48106
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
John C. Widman
Safety Officer
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
CELLULAR RESPONSE TO PULSATILE MOLECULAR SIGNALS, RATHER THAN STEADY-STATE SIGNALS, MAY BE NEARLY UNIVERSAL AND, IF DEMONSTRATED, WILL BE A DISCOVERY OF FUNDAMENTAL IMPORTANCE. THE AIM OF THIS RESEARCH IS TO CONSTRUCT AND TEST A UNIQUE CELL MICRO-PERIFUSION SYSTEM CAPABLE OF MAKING DYNAMIC MEASUREMENTS ON-LINE TO IDENTIFY WHAT PULSATILE SIGNAL CHARACTERISTICS (COMPOUNDS, PULSE HEIGHT (CONCENTRATION), PULSE WIDTH, ORDER AND TIMING) EVOKE CELLULAR RESPONSE. KMS FUSION WILL DEVELOP THE PERIFUSION SYSTEM AND BIOLOGICAL EXPERIMENTS WILL BE PERFORMED AT THE PROGRAM FOR THE STUDY OF REPRODUCTION AND DIFFERENTIATION OF THE UNIVERSITY OF MICHIGAN. WE EXPECT TO ESTABLISH THE FEASIBILITY AND IMPORTANCE OF USING DYNAMIC, ON-LINE, PERIFUSION SYSTEMS FOR THE STIMULATION AND ANALYSIS OF CELLS AND TISSUES IN VITRO. A FAMILY OF MARKETABLE INSTRUMENTS SHOULD EVOLVE, PROVIDING POWERFUL, FLEXIBLE WAYS TO MONITOR THE DYNAMICS OF LIVING CELLS IN RESPONSE TO A VARIETY OF DRUG REGIMENS, TOXINS, ENVIRONMENTAL OR OTHER SAMPLES. SUCH INSTRUMENTS MIGHT BE INDISPENSABLE TO PHARMACEUTICAL HOUSES, INDUSTRIAL FIRMS NEEDING PROCESS CONTROL OF BIOLOGICAL PROCESSES AND OF USE IN MEDICAL DIAGNOSIS.

* information listed above is at the time of submission.

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