Antibody Prophylaxis and Therapy of Flavivirus Infection

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$969,452.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI060217-01
Agency Tracking Number:
AI060217
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
L2 DIAGNOSTICS, LLC
L2 DIAGNOSTICS, LLC, BOX 8175, NEW HAVEN, CT, 94904
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RAYMOND KOSKI
(203) 589-2029
RAYMOND.KOSKI@L2DX.COM
Business Contact:
MARTIN MATTESSICH
(203) 737-1952
MJMATT@IX.NETCOM.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The overall goal of this project is to develop antibody therapy and prophylaxis to treat and prevent life-threatening flavivirus infections. West Nile virus is the focus of Phase I studies. Our working hypothesis is that high titer anti-envelope protein antibodies can protect humans against flaviviruses. Passive immunization is an accepted medical practice that can protect against infection. Immunizing animals with a proprietary recombinant West Nile virus envelope protein antigen induces high titer antibodies. These antibodies protect mice from a lethal dose of West Nile virus when administered i.p. to natve or infected mice. Protective anti-envelope protein antibodies will be produced using standard equine immunization and antibody purification protocols. IgG antibody, F(ab')2 and Fab administered i.v. or i.c.v will be evaluated in a mouse model of neurotropic WN virus infection. Phase I experiments will also begin developing neutralizing antibodies to related flavivirus envelope proteins. In Phase II, we expect to obtain preclinical data on an equine antibody preparation to protect humans and animals from West Nile virus infection; produce protective antibodies for related flaviviruses; and develop humanized anti-envelope protein monoclonal antibodies. This project will provide clinicians, public health officials, and veterinarians with new means to manage flavivirus virus outbreaks.

* information listed above is at the time of submission.

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