Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: CA75716-01
Agency Tracking Number: 39440
Amount: $98,975.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1500 SAN JUAN HILLS, STE 203, Las Vegas, NV, 89134
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: (702) 255-2934
Research Institution
Photodynamic therapy has been approved for certain indications in the USA, Japan, Canada, France and Netherlands. The only drug approved, Photofrin, is not ideal and a significant research effort has led to the development of second generation sensitizers. Many of these agents are hydrophobic and need formulation to be administered. This significantly increases the time and cost of drug preparation, in many cases by well over 100%. These factors are increasingly important in today's climate of cost containment in the health industry. This Phase I application addresses the problems associated with delivery of hydrophobic sensitizers by the preparation and biological evaluation of more water soluble photodynamic agents. Synthesis will concentrate on phthalocyanine chemistry with ease of synthesis, potential applicability to scale-up and minimalization of isomer formation as priorities. Given the 6 month time frame of this study, biological evaluation will consist of an assessment of in vivo tumor response in a rat chondrosarcoma model and a mechanistic study to delineate the contributions of direct versus indirect cell kill mechanisms to the photodynamic response. The goal of this study is the identification of candidate sensitizers for further evaluation, leading to the submission of an Investigational New Drug application to the FDA.

* Information listed above is at the time of submission. *

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