CAMERA SYSTEM FOR TWO-DIMENSIONAL ELECTROPHORESIS GELS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4951
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Large Scale Biology Corp.
7503 Standish Pl, Rockville, MD, 20855
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Norman Gulack Anderson
 Principal Investigator
 (301) 881-2600
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WHILE A VARIETY OF SCANNERS AND CAMERA SYSTEMS HAVE BEEN DESCRIBED FOR ACQUIRING TWO-DIMENSIONAL ELECTROPHORETIC GEL PATTERNS FOR DISPLAY, ANALYSIS, INTERCOMPARISON, AND REPRODUCTION, NONE SOLVES ALL OF THE PROBLEMS OF IMAGE ACQUISITION AND IMAGE IDENTIFICATION IN A SATISFACTORY MANNER. THIS PROPOSAL IS FOR THE DEVELOPMENT OF A 70-MM PRECISION PIN-REGISTERED CAMERA SYSTEM FOR PHOTOGRAPHING TWO-DIMENSIONAL ELECTROPHORETIC PATTERNS. A SECOND OPTICAL PATH INCLUDES IN THE NEGATIVE A CRT-GENERATED IDENTIFICATIONAND DATA DISPLAY AREA. A UNIQUE DESIGN REDUCES LENS FLARE TO A MINIMUM. USING A THREE-COLOR FILTER SYSTEM, COLOR SEPARATION NEGATIVES MAY ALSO BE MADE IN SEQUENCE FOR SUBSEQUENT COLOR REPRODUCTION. THE CAMERA SYSTEM IS ALSO A 70-MM PRINTER THAT EXPOSES POSITIVE FILM TO THE NEGATIVE FILM. THE POSITIVES MAY BE VIEWED AND INTERCOMPARED ON A MERGING COMPARATOR, OR DIGITIZED FOR COMPUTERIZED IMAGE ANALYSIS. INCORPORATED INTO THE PRINTING SYSTEM IS A UNIQUE TECHNIQUE FOR REMOVING DENSE BACKGROUND AREAS SUCH ASMAY EXIST IN SILVER-STAINED GELS. THE SYSTEM IS FLEXIBLE RETAINS THE ORIGINAL IMAGE FOR STUDY OR REPRODUCTION. ONE CENTRALIZED DIGITIZING SCANNER CAN SERVE NUMEROUS REMOTE 70-MM GEL CAMERAS.

* information listed above is at the time of submission.

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