FAST CLINICAL IMMUNOVIROLOGY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7107
Amount: $48,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Large Scale Biology Corp
7503 Standish Place, Rockville, MD, 20855
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 NORMAN G ANDERSON PHD
 (301) 424-5989
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVES OF THIS PROJECT ARE TO DEVELOP NEW AND RAPID METHODS FOR DETECTING, ISOLATING, AND CHARACTERIZING NEW VIRUSES, KNOWN VIRIONS, VIRAL ANTIGENS, AND ANTIBODIES TO KNOWN PATHOGENIC VIRUSES. THE METHODS TO BE EXPLORED DEPEND ON UNIQUE COMBINATIONS OF CENTRIFUGAL TECHNIQUES, ANDTHE BANDING DENSITIES AND SEDIMENTATION COEFFICIENTS OF BOTHINDIVIDUAL SPECIES OF VIRUS PARTICLES AND OF FLUORESCENT AND NONFLUORESCENT LATEX PARTICLES. THE METHODS INCLUDE (IN ORDER OF INCREASED INSTRUMENTATIONAL COMPLEXITY) DENSITY-SEPARATED FLUORESCENT IMMUNOAGGREGATES, RATE-SEPARATED FLUORESCENT IMMUNOAGGREGATES, ISOPYCNOMETRIC VIRUS DETECTION, AND TWO-DIMENSIONAL CENTRIFUGAL VIRUS ISOLATION. WITH THESE METHODS IT IS PROPOSED THAT NEW VIRUSES CAN BE RAPIDLY ISOLATED AND CHARACTERIZED; TESTS CAN BE DEVELOPED THAT WILL YIELD PRECISE VIRUS TITERS, ALLOWING METHODS FOR GROWING THE VIRUS TO BE EVALUATED EVEN WHEN VERY POOR YIELDS ARE OBTAINED; AND RAPID METHODS FOR DIAGNOSIS OF VIRAL DISEASES BASED ON VIRION DETECTION, ANTIGEN DETECTION,OR ANTIBODY DETECTION CAN BE DEVELOPED. THE PRINCIPLES OF THE METHODS WILL BE STUDIED IN PHASE I. IN PHASE II, A PROTOTYPE WILL BE DEVELOPED AND INITIAL APPLICATIONS WILL BEMADE.

* information listed above is at the time of submission.

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