THE PURPOSE OF THIS PROPOSAL IS TO DEVELOP A LASER BASED SYSTEM THAT WILL EXCITE FLUORESCENCE IN PREMALIGNANT AND MALIGNANT TISSUE FOLLOWING TREATMENT OF THE PATIENT WITH THE DYE HEMATOPORPHYRIN DERIVATIVE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$47,680.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3076
Agency Tracking Number:
3076
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
151 Kalmus Drive, Suite H3, Costa Mesa, CA, 92626
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMES ASHBY
PRINCIPAL INVESTIGATOR
(714) 432-9660
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THIS PROPOSAL IS TO DEVELOP A LASER BASED SYSTEM THAT WILL EXCITE FLUORESCENCE IN PREMALIGNANT AND MALIGNANT TISSUE FOLLOWING TREATMENT OF THE PATIENT WITH THE DYE HEMATOPORPHYRIN DERIVATIVE. THE SPECIFIC OBJECTIVES OF THIS PROPOSAL ARE: 1.TO INTERFACE A KRYPTON ION LASER (406416 NM) WITH APPROPRIATE FIBER OPTICS FOR DELIVERY OF LIGHT TO A MALIGNANT TISSUE SITE. 2.TO COMBINE AN APPROPRIATE FIBER OPTIC DETECTION SYSTEM WITH THE ABOVE SYSTEM SO THAT THE FLUORESCENT MALIGNANT SITE CAN BE VISUALIZED EITHER DIRECTLY AND/OR INDIRECTLY USING A LOW LIGHT-LEVEL DETECTOR. 3.TO PERFORM PRELIMINARY STUDIES TO DETERMINE THE FEASIBILITY OF INTERFACING THE IMAGE DETECTOR WITH REAL-TIME COMPUTER BASED IMAGE ENHANCEMENT IN ORDER TO INCREASE THE SENSITIVITY AND PRECISION OF THE TECHNIQUE. 4.TO PERFORM FEASIBILITY TESTING ON ESTABLISHED ANIMAL TUMOR MODELS FOLLOWED BY TESTING OF THE PROTOTYPE IN A CLINICAL SETTING.

* information listed above is at the time of submission.

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