CONTINUOUS MONITORING OF DOPPLER CARDIAC OUTPUT

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$500,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
484
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Lawrence Medical Systems Inc.
2849-152nd Ave. N.e., Redmond, WA, 98052
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Stephen R. Barnes
 (206) 881-7717
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVE OF THIS STUDY IS TO DEVELOP A SYSTEM FOR CONTINUOUSLY MONITORING CARDIAC OUTPUT BY THE USE OF DOP- PLER ULTRASOUND FROM THE ESOPHAGUS. THE PRINCIPLE OF OPERATION IS THAT BLOOD VELOCITY AT THE MEASUREMENT SITE, THE TRANSVERSE AORTA, WILL BE PROPOR- TIONAL TO THE BLOOD FLOW. IT HAS ALREADY BEEN DEMONSTRATED THAT CONTINUOUS WAVE DOPPLER CAN ACCURATELY ASSESS STROKE VOLUME IN MAN. RECENT STUDIES BY OTHERS HAVE SHOWN THAT FLOW VELOCITIES CAN BE DETECTED BY PULSED DOPPLER SENSORS FROM THE ESOPHAGUS. EXPERIMENTS ARE PLANNED TO QUANTIFY THE REQUIREMENTS FOR AN ESOPHAGEAL PROBE DESIGN AND PLACE- MENT TECHNIQUE SO AS TO BE ABLE TO CONTINUOUSLY MONITOR SUCH FLOW. THE GRANTEE HAS SEVERAL SPECIFIC OBJECTIVES: 1) DEVELOP- MENT OF A CONTINUOUS WAVE ESOPHAGEAL TRANSDUCER SYSTEM; 2) TESTING OF THIS SYSTEM IN ANIMALS UNDER CONDITIONS SIMILAR TO CLINICAL SITUATIONS TO VERIFY OPERATION AND REFINEMENT OF PLACEMENT TECHNIQUE; 3) PERFORM ANY NECESSARY REFINE- MENTS OF THE TRANSDUCER AND SYSTEM; AND 4) EVALUATE THE SYSTEM IN 20 HUMAN SUBJECTS IN THE INTENSIVE CARE UNIT AND OPERATING ROOM. THE OBJECTIVE OF THE CLINICAL EVALUATIONS ARE TO REFINE FURTHER THE DESIGN OF THE SYSTEM, TO ASSESS THE FEASIBILITY OF THE TECHNIQUE IN CLINICAL SETTINGS, AND TO PROVIDE THE BASIS FOR A MORE EXTENSIVE EVALUATION TO ASSESS THE EFFICACY OF THE TECHNIQUE AND TO DEVELOP APPLI- CATIONS TO THE PATIENT CARE. AS WELL AS RECOVERY OF NUTRIENTS AND REUSE OF WASTEWATER.

* information listed above is at the time of submission.

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