AN IMMUNOSPECIFIC ASSAY FOR HUMAN PAPILLOMAVIRUSES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$499,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
4695
Agency Tracking Number:
4695
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
21705 Evergreen Road, Southfield, MI, 48075
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Jin Po (james) Lee
Principal Investigator
(313) 353-2620
Business Contact:
() -
Research Institute:
n/a
Abstract
THE PRIMARY OBJECTIVE OF THIS EFFORT IS TO PROVIDE A METHODOLOGY FOR ASSAY OF HUMAN PAPILLOMAVIRUS INFECTION IN HUMAN CELLS BY UTILIZING MONOCLONAL ANTIBODY TECHNOLOGY IN THE DEVELOPMENT OF AN IMMUNOCYTOLOGIC ASSAY. HUMAN PAPILLOMAVIRUS INFECTION HAS BEEN STRONGLY ASSOCIATED WITH CERVICAL CANCER, AS WELL AS PRECANCEROUS LESIONS AND IS CONSIDERED TO BE A MAJOR HEALTH PROBLEM IN THIS COUNTRY AND WORLDWIDE. IT IS EASILY TREATABLE FOLLOWING EARLY DIAGNOSIS, MAKING THE CLINICAL NEED AND USEFULNESS OF AN OBJECTIVE ASSAY USED AS AN ADJUNCT TO PAPANICOLAOU SMEARS APPARENT. THE PHASE I EFFORT CONSISTS OF THE PREPARATION OFBOVINE PAPILLOMAVIRUS PROTEINS AS IMMUNOGENS AND THE PRODUCTION AND INITIAL CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO THE GENUS-SPECIFIC CAPSID PROTEIN OF PAPILLOMAVIRUSES FROM THE HYPERIMMUNIZATION OF MICE. COMPLETE CHARACTERIZATION OF THE MONOCLONAL ANTIBODIES AND THEIR INCORPORATION INTO AN OBJECTIVE IMMUNOCYTOCHEMICAL ASSAY FOR THE DETECTION OF PAPILLOMAVIRUS INFECTION IN HUMANS IS PLANNED FOR PHASE II. THE UNIQUENESS OF THE PRODUCT DERIVES FROM ANTICIPATED IMPROVEMENTS IN SENSITIVITY, SPECIFICITY, AND COST OVER EXISTING METHODOLOGIES.

* information listed above is at the time of submission.

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