AN IMMUNOSPECIFIC ASSAY FOR HUMAN PAPILLOMAVIRUSES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4695
Amount: $499,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Leeco Diagnostics Inc.
21705 Evergreen Road, Southfield, MI, 48075
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jin Po (james) Lee
 Principal Investigator
 (313) 353-2620
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PRIMARY OBJECTIVE OF THIS EFFORT IS TO PROVIDE A METHODOLOGY FOR ASSAY OF HUMAN PAPILLOMAVIRUS INFECTION IN HUMAN CELLS BY UTILIZING MONOCLONAL ANTIBODY TECHNOLOGY IN THE DEVELOPMENT OF AN IMMUNOCYTOLOGIC ASSAY. HUMAN PAPILLOMAVIRUS INFECTION HAS BEEN STRONGLY ASSOCIATED WITH CERVICAL CANCER, AS WELL AS PRECANCEROUS LESIONS AND IS CONSIDERED TO BE A MAJOR HEALTH PROBLEM IN THIS COUNTRY AND WORLDWIDE. IT IS EASILY TREATABLE FOLLOWING EARLY DIAGNOSIS, MAKING THE CLINICAL NEED AND USEFULNESS OF AN OBJECTIVE ASSAY USED AS AN ADJUNCT TO PAPANICOLAOU SMEARS APPARENT. THE PHASE I EFFORT CONSISTS OF THE PREPARATION OFBOVINE PAPILLOMAVIRUS PROTEINS AS IMMUNOGENS AND THE PRODUCTION AND INITIAL CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO THE GENUS-SPECIFIC CAPSID PROTEIN OF PAPILLOMAVIRUSES FROM THE HYPERIMMUNIZATION OF MICE. COMPLETE CHARACTERIZATION OF THE MONOCLONAL ANTIBODIES AND THEIR INCORPORATION INTO AN OBJECTIVE IMMUNOCYTOCHEMICAL ASSAY FOR THE DETECTION OF PAPILLOMAVIRUS INFECTION IN HUMANS IS PLANNED FOR PHASE II. THE UNIQUENESS OF THE PRODUCT DERIVES FROM ANTICIPATED IMPROVEMENTS IN SENSITIVITY, SPECIFICITY, AND COST OVER EXISTING METHODOLOGIES.

* information listed above is at the time of submission.

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