DEVELOPMENT OF A DETECTOR FOR ELECTROPHILIC CARCINOGENS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$48,265.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
13761
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Life Systems Inc
24755 Highpoint Rd, Cleveland, OH, 44122
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dennis B Heppner
(216) 464-3291
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PHASE I OBJECTIVES ARE: (1) DEVELOP AN ELECTRONIC SAMPLING DEVICE THAT PROVIDES A MEASURE OF THE ELECTROPHILICITY OF CHEMICALS IN LIQUIDS; (2) COMPARE THE RESPONSES OF THIS DEVICE WITH THOSE OF A PHYSICOCHEMICAL CARCINOGEN-SCREENING TEST (THE KE TEST) FOR KNOWN GENOTOXIC AND NONGENOTOXIC CARCINOGENS AND NONCARCINOGENS; (3) APPLY AN ESTABLISHED BATTERY SELECTION METHOD, THE CPBS OR CARCINOGENICITY PREDICTION AND BATTERY SELECTION METHOD, TO DETERMINE HOW THE ELECTRONIC DEVICE CAN BE USED MOST EFFICACIOUSLY IN A BATTERY OF CARCINOGEN-SCREENING TESTS; AND (4) INITIATE THE DEVELOPMENT OF AN ALTERNATIVE MEANS OF PRODUCING EXCESS ELECTRONS FOR USE WITH THE ELECTRONIC SAMPLING DEVICE THAT DOES NOT REQUIRE IONIZING RADIATION. ACCOMPLISHING THESE FOUR OBJECTIVES WILL PROVIDE A FIRM BASIS FOR THE PHASE II OBJECTIVE OF DEVELOPING AN ELECTRONICCARCINOGEN-MONITORING SYSTEM THAT COULD BE USED IN A VARIETY OF APPLICATIONS HAVING COMMERCIAL POTENTIAL THAT EXCEEDS $100 MILLION/YEAR.

* information listed above is at the time of submission.

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