All Solid State Laser for DNA Sequencing
Department of Health and Human Services
1 R43 RR09853-1,
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Small Business Information
Lightwave Electronics Corp.
1161 San Antonio Road, Mountain View, CA, 94043
Socially and Economically Disadvantaged:
AbstractNumerous biomedical analysis techniques utilize laser-induced-fluorescence detection. Thisprovides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The mostcommonly used laser for these applications is the Ar-ion laser, since it is well matched to the excitationwavelengths of the most widely used dyes. However this laser is less than optimal for theseapplications: it is fairly large and has low efficiency, so it dissipates much excess heat in the instrumentand consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary.This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetimelaser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedicalinstrumentation. It would be based on new InGaAs diode lasers. The near-infrared output of such adiode would he frequency-doubled in a nonlinear crystal to achieve a wavelength of 510 nm, which isoptimal for DNA sequencing. We will use a resonant doubling cavity to achieve good conversionefficiency. The Phase II follow-on would entail developing a 510 nm source optimized for use in DNAsequencers and other biomedical instruments.
* information listed above is at the time of submission.