All Solid State Laser for DNA Sequencing

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 RR09853-1,
Agency Tracking Number: 25274
Amount: $78,620.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Lightwave Electronics Corp.
1161 San Antonio Road, Mountain View, CA, 94043
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Thomas Steele
 (415) 962-0755
Business Contact
Phone: () -
Research Institution
Numerous biomedical analysis techniques utilize laser-induced-fluorescence detection. Thisprovides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The mostcommonly used laser for these applications is the Ar-ion laser, since it is well matched to the excitationwavelengths of the most widely used dyes. However this laser is less than optimal for theseapplications: it is fairly large and has low efficiency, so it dissipates much excess heat in the instrumentand consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary.This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetimelaser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedicalinstrumentation. It would be based on new InGaAs diode lasers. The near-infrared output of such adiode would he frequency-doubled in a nonlinear crystal to achieve a wavelength of 510 nm, which isoptimal for DNA sequencing. We will use a resonant doubling cavity to achieve good conversionefficiency. The Phase II follow-on would entail developing a 510 nm source optimized for use in DNAsequencers and other biomedical instruments.

* information listed above is at the time of submission.

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