All-Solid-State Laser for Biomedical Instrumentation

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22409
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1161 San Antonio Road, Mountain View, CA, 94043
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Thomas R. Steele
 (415) 962-0755
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Numerous biomedical analysis techniques, such as flow cytometry and confocal microscopy, utilize laser-induced-fluorescence detection. This provides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The most commonly used laser for these applications is the 488nm Ar-ion laser, since it is well- matched to the excitation wavelength of fluorescein dyes which are the most widely used. However, this laser is less than optimal for these applications: it is fairly large, has low efficiency, it dissipates excess heat in the instrument, and consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary. This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetime laser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedical instrumentation. It would be based on new InGaAs disde lasers. The near-infrared output of this device would be frequency-doubled in a nonlinear crystal to achieve a wavelength of approximately 490nm, optimal for these applications. We will use a resonant doubling cavity to achieve good conversion efficiency. The Phase II follow-on would entail developing a 490nm source optimized for use in biomedical instruments.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government