All-Solid-State Laser for Biomedical Instrumentation

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22409
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1161 San Antonio Road, Mountain View, CA, 94043
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Thomas R. Steele
 (415) 962-0755
Business Contact
Phone: () -
Research Institution
Numerous biomedical analysis techniques, such as flow cytometry and confocal microscopy, utilize laser-induced-fluorescence detection. This provides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The most commonly used laser for these applications is the 488nm Ar-ion laser, since it is well- matched to the excitation wavelength of fluorescein dyes which are the most widely used. However, this laser is less than optimal for these applications: it is fairly large, has low efficiency, it dissipates excess heat in the instrument, and consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary. This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetime laser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedical instrumentation. It would be based on new InGaAs disde lasers. The near-infrared output of this device would be frequency-doubled in a nonlinear crystal to achieve a wavelength of approximately 490nm, optimal for these applications. We will use a resonant doubling cavity to achieve good conversion efficiency. The Phase II follow-on would entail developing a 490nm source optimized for use in biomedical instruments.

* Information listed above is at the time of submission. *

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