THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4884
Amount: $34,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Lipid Specialties
21 Tioga Way, Marblehead, MA, 01945
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DR BARRY SEARS
 PRINCIPAL INVESTIGATOR
 (617) 639-2400
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL. WITH A 1% MORTALITY RATE AND SUBSTANTIAL HOSPITALIZATION COSTS, A SEARCH FOR LESS EXPENSIVE AND SAFER TREATMENTS FOR GALLSTONE ELIMINATION IS WARRANTED. IT HAS BEEN SHOWN THAT GALLSTONES CONSIST PRIMARILY OF CHOLESTEROL AND THAT THEIR FORMATION IS A CONSEQUENCE OF EXCEEDING THE SOLUBILITY LIMITS OF CHOLESTEROL IN THE BILE. AS A RESULT, IT HAS BEENPROPOSED THAT ORAL TREATMENT WITH SUITABLE BILE ACIDS MAY ACT AS GALLSTONE DISSOLVING AGENTS, THEREBY ELIMINATING THE NEED FOR SURGERY. THE GOAL OF THIS PROJECT IS TO DEMON- STRATE THAT SHORT CHAIN ANALOGS OF HEAD GROUP MODIFIED PHOSPHATIDYLCHOLINES HAVE SUPERIOR SOLUBILIZING PROPERTIES WHEN COMPARED TO OTHER POTENTIAL CHOLESTEROL SOLUBILIZING AGENTS AND RELATIVE TO THE AMOUNT AND SPEED AT WHICH THEY CAN DISSOLVE PRE-EXISTING CHOLESTEROL CRYSTALS. SHOULD PHASE I STUDIES BE SUCCESSFUL, PHASE II STUDIES WOULD THEN CONCENTRATE ON THE ABILITY OF MODIFIED PHOSPHATIDYLCHOLINES TAKEN ORALLY TO ENTER INTO THE ENTEROHEPATIC CIRCULATION IN ANIMAL MODELS. FUTURE TESTING WOULD CONSIST OF PRELIMINARY HUMAN STUDIES.

* information listed above is at the time of submission.

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