A HOMOGENEOUS ASSAY FOR MIXED CONNECTIVE TISSUE DISEASE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7866
Agency Tracking Number:
7866
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10515 Research Dr, Knoxville, TN, 37923
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
WE PROPOSE TO DEVELOP A HOMOGENEOUS, LIPOSOME-BASED IMMUNOASSAY FOR ANTINUCLEAR ANTIBODY (ANA) DISEASES. IN THE PHASE I STUDIES, WE WILL DEMONSTRATE THE FEASIBILITY OF THE APPROACH FOR ONLY ONE ANA DISEASE, I.E., THE MIXED CONNECTIVE TISSUE DISEASE. THE MAJOR NUCLEAR ANTIGEN U1-RNP, FOR THIS AUTOIMMUNE DISEASE HAS BEEN CLONED IN BACTERIA WITH A PROPRIETARY TECHNOLOGY. WE WILL INCORPORATE THE CLONED U1-RNP INTO LIPOSOME MEMBRANE TO PREPARE TARGET-SENSITIVE LIPOSOMES (ALSO A PROPRIETARY TECHNOLOGY OF LIPOGEN, INC.). GLUCOSE-6-PHOSPHATE DEHYDROGENASE WILL BE ENTRAPPED AS A REPORTER ENZYME. A HOMOGENEOUS, COLORIMETRIC, INHIBITION ASSAY WILL BE DEVELOPED AS A PROTOTYPE FOR FUTURE DIAGNOSTIC PRODUCTS WHICH WILL INCLUDE OTHER ANA ANTIBODIES.

* information listed above is at the time of submission.

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