A HOMOGENEOUS ASSAY FOR MIXED CONNECTIVE TISSUE DISEASE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7866
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
10515 Research Dr, Knoxville, TN, 37923
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE PROPOSE TO DEVELOP A HOMOGENEOUS, LIPOSOME-BASED IMMUNOASSAY FOR ANTINUCLEAR ANTIBODY (ANA) DISEASES. IN THE PHASE I STUDIES, WE WILL DEMONSTRATE THE FEASIBILITY OF THE APPROACH FOR ONLY ONE ANA DISEASE, I.E., THE MIXED CONNECTIVE TISSUE DISEASE. THE MAJOR NUCLEAR ANTIGEN U1-RNP, FOR THIS AUTOIMMUNE DISEASE HAS BEEN CLONED IN BACTERIA WITH A PROPRIETARY TECHNOLOGY. WE WILL INCORPORATE THE CLONED U1-RNP INTO LIPOSOME MEMBRANE TO PREPARE TARGET-SENSITIVE LIPOSOMES (ALSO A PROPRIETARY TECHNOLOGY OF LIPOGEN, INC.). GLUCOSE-6-PHOSPHATE DEHYDROGENASE WILL BE ENTRAPPED AS A REPORTER ENZYME. A HOMOGENEOUS, COLORIMETRIC, INHIBITION ASSAY WILL BE DEVELOPED AS A PROTOTYPE FOR FUTURE DIAGNOSTIC PRODUCTS WHICH WILL INCLUDE OTHER ANA ANTIBODIES.

* Information listed above is at the time of submission. *

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