"STEALTH" LIPOSOME ENCAPSULATED HEMOGLOBIN--LOW TOXICITY BLOOD SUBSTITUTE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,318.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19348
Agency Tracking Number:
19348
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1050 Hamilton Court, Menlo Park, CA, 94025
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Danilo Lasic
(415) 323-9011
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OVERALL GOAL IS TO DEVELOP AN OXYGEN-CARRYING RED BLOOD CELL SUBSTITUTE TO REPLACE WHOLE BLOOD TRANSFUSIONS AND/OR AN OXYGEN-CARRYING PLASMA EXPANDER TO REPLACE PLASMA AND INTRAVENOUS FLUIDS USED TO TREAT TRAUMA VICTIMS. BY ENTRAPPING HEMOGLOBIN IN LONG-CIRCULATING "STEALTH " LIPOSOMES WHICH ARE DESIGNED TO BE LESS SUSCEPTIBLE TO PHAGOCYTOSIS BY THE RETICULOENDOTHELIAL SYSTEM (RES) THAN ORDINARY LIPOSOMES, WE HOPE TO DEVELOP AN OXYGEN-CARRYING SYSTEM THAT IS SUBSTANTIALLY LESS IMMUNOTOXIC THAN OTHER EXPERIMENTAL SYSTEMS UNDER DEVELOPMENT, SUCH AS ORDINARY LIPOSOMES. IN THE PRESENT PROGRAM, WE PLAN TO INVESTIGATE STEALTH LIPOSOME ENTRAPPED HEMOGLOBIN IN TERMS OF ITS PHARMACOKINETICS, SYSTEMIC TOXICITY, CYTOTOXIC EFFECTS AND IMPAIRMENT/BLOCKAGE OF THE RES. STEALTH LIPOSOMES CONTAIN POLYETHYLENE GLYCOL LLIPD DERIVATIVES WHICH SHIELD THESE LIPIS PARTICLES FROM RES RECOGNITION AND UPTAKE AND SIGNIFICANTLY INCREASE CIRCULATION TIME IN THE BLOODSTREAM. THE LONG-TERM OBJECT OF THIS PROGRAM IS THE DEVELOPMENT OF STEALTH LIPOSOME HEMOGLOBIN FORMULATIONS MEETING PHARMACEUTICAL STANDARDS WITH RESPECT TO SAFETY, EFFICAY, SHELF-LIFE AND MANUFACTURABILITY.

* information listed above is at the time of submission.

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