A RELIABLE TEST FOR GASTROINTESTINAL LESIONS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$264,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
2990
Agency Tracking Number:
2990
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2082 Abbey Lane, Campbell, CA, 95008
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul J. Lawrence
Principal Investigator
(408) 379-6309
Business Contact:
() -
Research Institute:
n/a
Abstract
FECAL OCCULT BLOOD TESTS (FOBT) ARE COMMONLY USED TO DETECT BLOOD RELEASED FROM GI LESIONS. FOR EXAMPLE, COLORECTAL CANCER IS THE MOST COMMON SERIOUS CANCER IN THE U.S. (100,000 NEW CASES AND 50,000 DEATHS ANNUALLY). BECAUSE IT IS RELATIVELY SLOWLY PROGRESSIVE WITH A LONG ASYMPTOMATIC PERIOD, COLORECTAL CANCER PROVIDES AN IDEAL OPPORTUNITY FOR EARLY DETECTION AND SUCCESSFUL THERAPY. SINCE COLORECTAL CANCERS AND PRECARIOUS LESIONS FREQUENTLY BLEED, FOBT ARE A RATIONAL ATTEMPT AT EARLY DETECTION. SIMILARLY, HOSPITALS AND PHYSICIANS FREQUENTLY UTILIZE FOBT TO DETECT AND MONITOR GI LESIONS NUMEROUS CLINICAL STUDIES ILLUSTRATE THAT CURRENT FOBT SUFFER FROM SERIOUS LIMITATIONS IN SENSITIVITY AND SPECIFICITY. UNFORTUNATELY PROPOSED ALTERNATIVES ARE NO LONGER SIMPLE, RAPID, COST-EFFECTIVE, ON-SITE THIS PROJECT WILL SHOW THE FEASIBILITY OF UPDATING CURRENT FOBT TECHNOLOGY TO IMPROVE CLINICAL PERFORMANCE WHILE RETAINING KEY USER ADVANTAGES.

* information listed above is at the time of submission.

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