A RELIABLE TEST FOR GASTROINTESTINAL LESIONS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2990
Amount: $264,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Litmus Concepts Inc.
2082 Abbey Lane, Campbell, CA, 95008
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Paul J. Lawrence
 Principal Investigator
 (408) 379-6309
Business Contact
Phone: () -
Research Institution
N/A
Abstract
FECAL OCCULT BLOOD TESTS (FOBT) ARE COMMONLY USED TO DETECT BLOOD RELEASED FROM GI LESIONS. FOR EXAMPLE, COLORECTAL CANCER IS THE MOST COMMON SERIOUS CANCER IN THE U.S. (100,000 NEW CASES AND 50,000 DEATHS ANNUALLY). BECAUSE IT IS RELATIVELY SLOWLY PROGRESSIVE WITH A LONG ASYMPTOMATIC PERIOD, COLORECTAL CANCER PROVIDES AN IDEAL OPPORTUNITY FOR EARLY DETECTION AND SUCCESSFUL THERAPY. SINCE COLORECTAL CANCERS AND PRECARIOUS LESIONS FREQUENTLY BLEED, FOBT ARE A RATIONAL ATTEMPT AT EARLY DETECTION. SIMILARLY, HOSPITALS AND PHYSICIANS FREQUENTLY UTILIZE FOBT TO DETECT AND MONITOR GI LESIONS NUMEROUS CLINICAL STUDIES ILLUSTRATE THAT CURRENT FOBT SUFFER FROM SERIOUS LIMITATIONS IN SENSITIVITY AND SPECIFICITY. UNFORTUNATELY PROPOSED ALTERNATIVES ARE NO LONGER SIMPLE, RAPID, COST-EFFECTIVE, ON-SITE THIS PROJECT WILL SHOW THE FEASIBILITY OF UPDATING CURRENT FOBT TECHNOLOGY TO IMPROVE CLINICAL PERFORMANCE WHILE RETAINING KEY USER ADVANTAGES.

* information listed above is at the time of submission.

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