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Development of a Clinical Decision Support Tool for Early-Detection of Directed Energy Induced Injury to the Retina

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH21C0015
Agency Tracking Number: H2-0616
Amount: $1,099,994.76
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHA192-001
Solicitation Number: 19.2
Solicitation Year: 2019
Award Year: 2021
Award Start Date (Proposal Award Date): 2021-04-22
Award End Date (Contract End Date): 2023-08-21
Small Business Information
Oceanit Center 828 Fort Street Mall, Suite 600
Honolulu, HI 96813-1111
United States
DUNS: 144540283
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Edward Pier
 (808) 531-3017
Business Contact
 Ken Cheung
Phone: (808) 531-3017
Research Institution

To develop a support tool for detecting retina damage, first a clinical decision support algorithm for rapid analysis of fundus images of the retina before and after laser injury was developed. The retinal images then went through a rigorous image enhancement phase, image data augmentation, and pixel normalization. Following the enhancement and augmentation processes, algorithms were developed to identify retinal abnormalities associated with laser damage. The laser –induced injury detection technology in human fundus images was optimized to achieve greater than 95% accuracy. Defining the parameters including ease of use, sensitivity and specificity, a strategy to acquire FDA approval as a clinical decision support tool will be developed. Algorithms will be transitioned to develop a fully functional prototype for commercial and clinical partners in Phase III.

* Information listed above is at the time of submission. *

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