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Optimal Rewarming Solutions for Cryopreserved Tissue Systems

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH21C0035
Agency Tracking Number: H2S-0016
Amount: $1,497,623.14
Phase: Phase II
Program: SBIR
Solicitation Topic Code: DHP 15-014
Solicitation Number: 15.1
Solicitation Year: 2015
Award Year: 2021
Award Start Date (Proposal Award Date): 2021-04-05
Award End Date (Contract End Date): 2023-08-04
Small Business Information
12345 W. 52nd Ave.
Wheat Ridge, CO 80033-1916
United States
DUNS: 181947730
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Girish Srinivas
 (303) 940-2321
Business Contact
 Mr. John D. Wright
Phone: (303) 940-2300
Research Institution

TDA, working with our collaborators, proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs, without allowing ice crystallization or mechanical damage that destroys the tissue. We have demonstrated the ability heat the sample at rates that far exceed the critical warming rate needed to suppress rewarming phase crystallization while simultaneously heating the sample uniformly enough to not induce mechanical damage. In the Phase II (a) project, we will improve our RF warming system by designing in improved feedback control, and scaling it up to handle larger samples. Success in the Phase II (a) project will ensure that the cryopreserved tissues pass from the vitrified state to the liquid state without forming crystalline ice (devitrification), and without the high thermal gradients which can lead to mechanical failure (fracture).

* Information listed above is at the time of submission. *

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