Medications for Alcohol Withdrawal/Brain Damage

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$748,637.00
Award Year:
1997
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 AA09930-01A1,
Award Id:
29075
Agency Tracking Number:
29075
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
505 Chicago Avenue, Evanston, IL, 60202
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Lawrence Snell
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
Chronic ethanol ingestion results in neurodegeneration with loss of neurons, glial proliferation anventricular and subarachnoid space. Work from our laboratories has demonstrated that chronic ethanolanimals produces an up-regulation of the excitatory N-methyl-D-aspartate (NMDA) subtype of glutamateWe have recently implicated the NMDA receptor system in induction of excitotoxic damage to various nduring ethanol withdrawal. We will test a series of compounds for their effectiveness in protectingcerebellum and cerebral cortex, grown in culture, against ethanol withdrawal induced excitotoxic damthe effectiveness of a novel NMDA receptor channel blocker, (+)-5- aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine(ADCI), which we have previously shown to be an excellent agent fobehavioral hyperexcitability (tremor, convulsions) during ethanol withdrawal in animals. We will alscycloleucine, and low efficacy partial agonists i.e.,; 1-neuroprotective actions in our cell culturewithdrawal excitotoxicity. Finally, we will test a series of gangliosides, including GM1 and GT1b, shave been touted to protect against glutamate-induced excitotoxicity without compromising the initiarelated events accompanying NMDA receptor stimulation. Our studies will generate an understanding ofcompounds are most effective for preventing ethanol withdrawal excitotoxicity and provide a basis foanimals in Phase II of the SBIR program.

* information listed above is at the time of submission.

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