Programmable Microfluidic Pump with Skin Penetration Enhancement for Drug Delivery

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$749,914.00
Award Year:
2006
Program:
SBIR
Phase:
Phase II
Contract:
FA8650-06-C-6650
Award Id:
72892
Agency Tracking Number:
F051-080-2144
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
67 East Evelyn Ave., Suite 3, Mountain View, CA, 94041
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
928805761
Principal Investigator:
MicahYairi
Senior Scientist
(650) 965-7772
m.yairi@lgrinc.com
Business Contact:
AnthonyO'Keefe
President
(650) 965-7772
a.okeefe@lgrinc.com
Research Institute:
n/a
Abstract
Soldiers in the field often perform difficult tasks under stressful situations for days at a time. Properly administered, pharmaceutical agents play a critical role helping soldiers operate at peak levels in these situations. Unfortunately, oral ingestion may result in unwanted drug peaks and valleys or gastrointestinal drug degeneration, while standard transdermal application is slow and limited to low-molecular-weight drugs. Los Gatos Research has developed a solution: a unique, lightweight microfluidic pump with no moving parts. Integrated inside a transdermal patch with a microprocessor and 3-Volt battery, it can provide days of continuous, programmable drug delivery. With skin penetration enhancers that increase skin permeability for medicines by orders of magnitude, the patch controllably and quickly delivers drugs transdermally. In Phase I, we demonstrated technical feasibility, creating this novel programmable drug delivery vehicle and demonstrating the ability to quickly deliver dextroamphetamine transdermally. Phase II will involve the development of smaller prototypes and more advanced electronic controls. Prototypes will be tested for reliability, programmability, response speed, and effectiveness for real-world conditions. Moreover, the pharmaceutical solutions will be refined to increase drug delivery rates even further. Prototypes will be delivered to the Air Force and, contingent on their approval, used in initial clinical trials.

* information listed above is at the time of submission.

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