Novel Instrumentation for Nitric Oxide Measurements in Biological Samples
Department of Health and Human Services
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Small Business Information
LOS GATOS RESEARCH
LOS GATOS RESEARCH, 67 E EVELYN AVE, STE 3, MOUNTAIN VIEW, CA, 94041
Socially and Economically Disadvantaged:
AbstractDESCRIPTION (provided by applicant): In this Small Business Innovative Research Phase I project, Los Gatos Research (LGR) proposes to develop and test a novel mid-infrared laser-based NO Analyzer for measurements of nitric oxide concentration in cellular m edia (biological samples) over a wide dynamic range (from picomole to micromole) and with a high sensitivity (picomole). The instrument will be based on LGR's patented Off-Axis ICOS technology. In this Phase I effort, LGR is collaborating with the Universi ty of Alabama Huntsville (UAH) to develop and deploy and test this novel portable instrument. System performance will be demonstrated first in gravimetrically prepared gas samples at LGR and subsequently in aqueous biological samples at UAH. The results wi ll be validated by direct comparison with conventional chemiluminescence analyzers (at LGR) and electrochemical probes (at UAH).
* information listed above is at the time of submission.