LOW-COST MODULES FOR PRYOGEN-FREE WATER

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$435,789.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
13631
Agency Tracking Number:
13631
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
111 E 27th St #204, Bryan, TX, 77803
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Oliver J Murphy
(409) 822-3149
Business Contact:
() -
Research Institute:
n/a
Abstract
WATER FOR PHARMACEUTICAL PREPARATION AND PARENTERAL THERAPY MUST BE OF HIGH CHEMICAL PURITY, STERILE, AND FREE FROM FEVER-PRODUCING BACTERIAL ENDOTOXINS. THE REMOVAL OF PYROGENS FROM WATER BY DISTILLATION IS EXPENSIVE. ACCEPTABLE ALTERNATIVES TO DISTILLATION REQUIRE METICULOUS MAINTENANCE, EXTENSIVE PRETREATMENT OF THE WATER, AND COSTLY (OFTEN REDUNDANT) BACKUP SYSTEMS TO ENSURE THE REMOVAL OF PYROGENS FROM SOLUTION. THESE HIGH COSTS HAVE FORCED MANY HOSPITALS TO ABANDON IN-HOUSE WATER PURIFICATIONIN FAVOR OF PREPACKAGED SOLUTIONS. THE GOAL OF THIS RESEARCH IS TO ESTABLISH THE TECHNICAL FEASIBILITY OF A LOW-COST ELECTROCHEMICAL DEVICE FOR THE DESTRUCTION OF PYROGENS IN WATER. THE DEVICE WILL BE BASED ON A SOLID POLYMER ELECTROLYTE AND WILL GENERATE OZONEAT THE ANODE AND AN ADDITIONAL CATALYTIC OXIDANT (H2O2) AT THE CATHODE; BOTH PRODUCTS WILL BE GENERATED DIRECTLY IN THE WATER STREAM. WHEN OZONE IS USED TO TREAT WATER IN COMBINATION WITH A SUITABLE CATALYST, THE LEVEL OF ORGANIC MATERIAL IN SOLUTIONCAN BE REDUCED TO BELOW PRESENT DETECTION LIMITS, AND PYROGENS ARE DESTROYED BY THIS TREATMENT. OZONE IS ATTRACTIVE BECAUSE IT DECOMPOSES RAPIDLY IN WATER TO FORM OXYGEN. SEVERAL CONVENIENT SYSTEMS ARE AVAILABLE FOR THE REMOVAL OF ANY EXCESS H2O2 FROM THE WATER; THUS, NO HARMFUL OXIDANT WILL REMAIN.

* information listed above is at the time of submission.

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