In Situ Crosslinked Collagen for an Advanced Wound Seal

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,996.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
22290
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Lynntech, Inc.
7610 Eastmark Drive, Suite 105, College Station, TX, 77840
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Douglas R. Miller
(409) 693-0017
Business Contact:
() -
Research Institution:
n/a
Abstract
While most soft tissue wounds are normally capable of reasonable repair without treatment, such repair occurs via scarring and contracture, often accompanied by some loss of appearance and/or function. Many wounds (e. g., burns, decubitus ulcers) require assistance to heal. Attempts to improve repair may be mechanical, where wound strength and barrier function is aided by a bioinert material, or a biologic approach which encourages regenerative repair. The former material must eventually be removed, but materials used for the latter are often deficient in mechanical strength, availability, or which are immunogenic or cytotoxic. We will develop a wound sealant composed primarily of collagen which can be gently but covalently crosslinked in situ via a proprietary catalyzed chemical reaction. Mechanical (barrier) strength will be achieved by the crosslinking of this material to itself and by direct covalent bonding to the tissue (eliminating problems with nonadherence), and it will provide a biocompatible (bioconductive) transition matrix for cellular infiltration and regenerative replacement. Time release antibiotics and growth factors can be included to lessen infection and speed healing. Flexibility in formulation and simplicity of design will allow widespread application in veterinary and human medical and dental practice.

* information listed above is at the time of submission.

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