Separation of Y-86 in One-Step Method for PET

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-FG02-05ER84287
Agency Tracking Number: 78757S05-I
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 04 b
Solicitation Number: DE-FG01-04ER04-33
Timeline
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
7607 Eastmark Drive, Suite 102, College Station, TX, 77840
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Teresia Moller
 Dr.
 (979) 693-0017
 teresia.moller@lynntech.com
Business Contact
 G. Duncan Hitchens
Title: Dr.
Phone: (979) 693-0017
Email: duncan.hitchens@lynntech.com
Research Institution
N/A
Abstract
78757S Yttrium-86 is a positron emitter with a 14.7 hour half-life and has proven to be suitable for the assessment of Y-90-pharmaceutical biodistribution with positron emission tomography (PET). Because Y-86 can be produced in a cyclotron by bombardment of a strontium target with ~14 MeV protons, it potentially is readily available. However, its routine production is not optimal because current purification methods are time consuming with several separation steps. This project will determine the suitability of an acidic inorganic ion exchange material of high strontium affinity and low yttrium affinity as the basis of a cartridge for fast and technically simple separation of high purity Y-86 from the acid dissolved irradiated target material in a single step. Ultimately, a compact separation cartridge will be designed that would have sufficient shielding and would be easy to ship and elute for the short-lived Y-86 positron emitter at a location outside the cyclotron facility. Phase I will involve the preparation and evaluation of a crystalline inorganic ion exchange material based on a metal oxide for separating Sr from Y in acidic conditions. Optimum synthesis conditions and composition of the crystalline material will be determined in order to obtain maximum uptake of strontium and minimum sorption of yttrium in the column. The affinity of the exchanger for strontium and yttrium will be determined in simple batch equilibration and column experiments using radioactive strontium and yttrium tracers. Commercial Applications and Other Benefits as described by the awardee: The technology should allow the Y-86 isotope to be shipped to users in small cartridges that are ready to be eluted. This would increase the availability and attractiveness of Y-86 to hospitals and research centers, which do not have access to expensive dedicated cyclotron facilities. The growth of PET is expected to continue with the number of procedures increasing ~35% in 2004. Thus the market for commercial application of new positron emitting isotopes such as Y-86 is significant.

* Information listed above is at the time of submission. *

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