Blood Brain Barrier (BBB) Permeable Encapsulating Agents for Effective Delivery of CNS-active Agents

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W81XWH-08-C-0087
Agency Tracking Number: C081-107-0061
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD08-107
Solicitation Number: 2008.1
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-05-09
Award End Date (Contract End Date): 2008-11-08
Small Business Information
7610 Eastmark Drive, College Station, TX, 77840
DUNS: 184758308
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Sriram Shankar
 Research Scientist
 (979) 693-0017
 sriram.shankar@lynntech.com
Business Contact
 G. Hitchens
Title: Vice President
Phone: (979) 693-0017
Email: duncan.hitchens@lynntech.com
Research Institution
N/A
Abstract
Drug transport in the central nervous system is highly regulated by the Blood-Brain Barrier (BBB). Most medicines, including many for treating cancer, Alzheimer’s, and stroke, do not meet essential criteria, such as lipophilicity and low molecular weight, required for appreciable transport into the brain. However, endogenous peptides, such as insulin or transferrin, and certain monoclonal antibodies, undergo receptor-mediated transport (RMT) across the BBB in vivo after binding to specific receptors or transporters localized within brain capillary endothelial cells (BCEC). Brain-delivery of brain-impermeable therapeutics can be accomplished by attaching them as payloads to these macromolecules. BBB transport of large molecule pharmaceutical payloads – including recombinant proteins, other antibodies, RNA interference drugs, and non-viral gene medicines – has been mediated in this fashion. Novel liposomal and polymer encapsulation methods have made it more facile to transport a large number of such molecules, attached as a single payload to a receptor-targeting mAb, across the BBB. In Phase I of this project, Lynntech, in collaboration with Dr. Abbott at Texas A&M Univ., will evaluate a suite of novel platforms for payload encapsulation and demonstrate their effective receptor-mediated transport and delivery in the brain.

* Information listed above is at the time of submission. *

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