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Sequential Isoelectric Point Separation of Proteins Using Non-Gel, Microfluidic System

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-08-C-0047
Agency Tracking Number: C081-101-0098
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD08-101
Solicitation Number: 2008.1
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-04-18
Award End Date (Contract End Date): 2008-10-18
Small Business Information
7610 Eastmark Drive
College Station, TX 77840
United States
DUNS: 184758308
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Gareth Hughes
 Sr. Research Scientist
 (979) 693-0017
Business Contact
 G. Hitchens
Title: Vice President
Phone: (979) 693-0017
Research Institution

The measurement of biochemical changes within the human body can provide a means to monitor a person’s physiological health. Many of the biochemicals that provide a snapshot of a person’s health are proteins. The challenge with measuring proteins is the existence of approximately ten orders of magnitude difference in concentration between the most abundant proteins in blood and those typically used to determine disease and physiological state. This proposed effort aims to develop a modular mass spectrometer for proteome profiling of readily available biological fluids comprising of user-configurable components for applications ranging from field-deployable pathogenic detection to customizable assays for biomedical diagnostics. The specific innovation is in the fabrication and integration of discrete microscale subsystems, including microfluidic chips for sample processing and miniature mass analyzers for spectroscopic analysis. The small form factor of all components enables the manufacture of compact mass spectrometers that will eventually reside in domestic to far-forward military medical facilities, clinics, doctor’s offices, or even nearby the patient in the hospital setting. The compact form factor will also enable the development of systems for far-forward deployment capable of on-site detection and monitoring of biological warfare agents / toxins.

* Information listed above is at the time of submission. *

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