UNIVERSAL CONTAMINATION-PREVENTING PIPET TIPS FOR PCR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,998.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16664
Agency Tracking Number:
16664
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
11408 Sorrento Valley Road, Su, Ite 202, San Diego, CA, 92121
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Macconnell, William P
Principal Investigator
(619) 452-2603
Business Contact:
1 R43 HG00293- 01
() -
Research Institute:
n/a
Abstract
THE WORK WILL LEAD TO THE DEVELOPMENT OF DISPOSABLE PIPET TIPS FOR PRE-EXISTING ADJUSTABLE MICROPIPETTORS THAT WILL COMPLETELY PREVENT CARRY-OVER CONTAMINATION IN POLYMERASE CHAIN REACTION (PCR) GENE AMPLIFICATION WORK. THE TIPS WILL BE SIMILAR TO CURRENT TIPS IN THAT THEY WILL BE MANUFACTURED TO FIT ALL COMMERCIALLY AVAILABLE PIPETTORS AND OFFERED AT A COST ONLY SLIGHTLY HIGHER THAN THE EXISTING TIPS. THIS ADAPTATION WILL ALSO BE USEFUL IN MANY LABORATORY PROCEDURES OTHER THAN PCR SUCH AS PIPETTING RADIOACTIVITY, ENZYMES AND NUCLEIC ACIDS; AVOIDING CONTAMINATION WITH THE SUBSTANCE BEING PIPETTED. IN PHASE I, MACCONNELL RESEARCH DEVISED A NEW CONCEPT FOR A CONTAMINATION-PREVENTING PIPET TIP THAT ALLOWS A NON-PERMEABLE BARRIER TO BE EVER PRESENT BETWEEN THE PIPETTOR AND SAMPLE FLUID. THIS PRODUCT CONCEPT WILL BE SUPERIOR IN BOTH PIPETTING PERFORMANCE AND ABILITY TO PREVENT CONTAMINATION WHEN COMPARED TO THE PERMEABLE BARRIER TIPS CURRENTLY BEING MARKETED. IN ADDITION, THE PRODUCT WILL BE LESS EXPENSIVE AND LESS WASTEFUL THAN THE POSITIVE DISPLACEMENT (DISPOSABLE PLUNGER) PIPETTING SYSTEMS CURRENTLY OFFERED. WE WILL DEVELOP THE NON-PERMEABLE BARRIER TIPS IN PHASE II, DURING WHICH EXTENSIVE EXPERIMENTATION WITH FLEXIBLE, THIN PLASTIC MOLDED BARRIERS WILL BE CARRIED OUT. THE COMPANY WILL WORK WITH AN EXPERIENCED BLOW MOLD FACILITY WHICH WILL GENERATE BOTH SINGLE PROTOTYPES AND PILOT SCALE MANUFACTURED PIECES TO BE TESTED IN OUR LABORATORIES.

* information listed above is at the time of submission.

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