A Multivalent Bacterial Vaccine for Atlantic Cod

Award Information
Agency: Department of Commerce
Branch: N/A
Contract: DG133R06CN0164
Agency Tracking Number: NOAA 06-88
Amount: $95,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: 8.1.11
Solicitation Number: NOAA-2006-1
Small Business Information
Maine BioTek, Inc.
P.O. Box 408, 259 Main Street, Winterport, ME, 04496
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Sharon Clouthier
 (207) 223-4662
Business Contact
 Sharon Clouthier
Title: President
Phone: (207) 223-4662
Email: sclouthier@hotmail.com
Research Institution
The goal of this project (Phase I ¿ III) is to develop a vaccine for the control of diseases in Atlantic cod caused by L. anguillarum and A. salmonicida. To accomplish this we have established the following sequential technical Phase I objectives: (1) identify bacterial growth conditions suitable for small-scale vaccine production, (2) determine the conditions for inactivation that result in the retention of immunoprotective properties and abolish infectivity of the bacteria, (3) standardize the content of a single dose of vaccine, (4) formulate the vaccine with or without adjuvant and (5) measure the safety and efficacy of the vaccine in Atlantic cod. The Phase II and III research efforts will include scale-up of vaccine production, determination of optimal vaccine dose, optimal adjuvant and vaccine formulation, duration and kinetics of the protective immune response elicited by the vaccine, vaccine safety and efficacy of the vaccine against heterologous bacteria.

* information listed above is at the time of submission.

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