A Multivalent Bacterial Vaccine for Atlantic Cod

Award Information
Agency:
Department of Commerce
Branch
n/a
Amount:
$95,000.00
Award Year:
2006
Program:
SBIR
Phase:
Phase I
Contract:
DG133R06CN0164
Agency Tracking Number:
NOAA 06-88
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Maine BioTek, Inc.
P.O. Box 408, 259 Main Street, Winterport, ME, 04496
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Sharon Clouthier
President
(207) 223-4662
sclouthier@hotmail.com
Business Contact:
Sharon Clouthier
President
(207) 223-4662
sclouthier@hotmail.com
Research Institution:
n/a
Abstract
The goal of this project (Phase I ¿ III) is to develop a vaccine for the control of diseases in Atlantic cod caused by L. anguillarum and A. salmonicida. To accomplish this we have established the following sequential technical Phase I objectives: (1) identify bacterial growth conditions suitable for small-scale vaccine production, (2) determine the conditions for inactivation that result in the retention of immunoprotective properties and abolish infectivity of the bacteria, (3) standardize the content of a single dose of vaccine, (4) formulate the vaccine with or without adjuvant and (5) measure the safety and efficacy of the vaccine in Atlantic cod. The Phase II and III research efforts will include scale-up of vaccine production, determination of optimal vaccine dose, optimal adjuvant and vaccine formulation, duration and kinetics of the protective immune response elicited by the vaccine, vaccine safety and efficacy of the vaccine against heterologous bacteria.

* information listed above is at the time of submission.

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