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Measurement of Biological Contamination of Water

Award Information
Agency: Environmental Protection Agency
Branch: N/A
Contract: 68D70018
Agency Tracking Number: 37898
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
P.O. Box 397266
Cambridge, MA 02139
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dr. M. Tekula
 () -
Business Contact
 Dr. M. Tekula
Phone: (617) 233-1785
Research Institution

Laser-induced fluorescence (LIF) can sometimes be used as a diagnostic device in biology and medicine. In general, LIF has difficulties in relating the fluorescence spectra to the concentration of the emitters within the tissue, in identifying different species, and in the possibility of destroying the molecules being probed if the wrong excitation wavelength is chosen. Many of the problems associated with fluorescence can be eliminated by the use of Raman scattering. Raman techniques allow the measurement of multiple species even in aqueous solutions (not accessible by infrared methods because of water absorption). However, spontaneous Raman techniques give very weak signals. Signal enhancement is possible by utilizing resonance Raman techniques. Both of these methods still suffer from the fact that spatial and, to some extent, temporal information is lost. This Phase I project will investigate a noninvasive, real-time, high resolution device for the detection of lifeforms such as Cryptosporidium or Giardia in situ in water. It also can be used to identify viable cysts and oocysts. This unique device is based on a variation of Raman scattering and can simultaneously measure the concentrations and temporal evolution of several different molecular species. Therefore, the technology may have applications in the medical field (virus and cholesterol measurements), in drug manufacturing and monitoring, and blood gas analysis. Furthermore, it may find applications in environment-related monitoring and analysis.

* Information listed above is at the time of submission. *

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