SBIR Phase I: New Labeling Reagents for Genetic Analysis

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$99,959.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
0740717
Award Id:
88318
Agency Tracking Number:
0740717
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1850 MILLRACE DRIVE, 1850 MILLRACE DRIVE, EUGENE, OR, 97403
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
869195859
Principal Investigator:
John Naleway
PhD
(541) 342-3760
jnaleway@uoregon.edu
Business Contact:
John Naleway
PhD
(541) 342-3760
jnaleway@uoregon.edu
Research Institute:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I research project aims to develop novel nucleic acid labeling reagents that can be used in living cells to monitor gene expression. Instead of relying on labeling the molecules using fluorescently labeled bases, the proposed approach relies on adding the label to the terminal phosphates. This would have great advantage over existing methods and would be a welcome addition to the tools of molecular analysis. Current detection of the changes in gene expression relies on the labeling of nucleic acids with fluorescent labels, which sometimes interferes with hybridization. Thus development of a technology that allows labeling of the nucleic acids in such a way so as to not affect the molecules? hybridization parameters would be a significant advance. Moreover, such a technology would make quantitiation of the hybridization event easier as the fluorescence intensity of the probe molecules would not be sequence dependent. In addition, the obviation of the need for enzyme incorporation and amplification methods would reduce the time and cost associated with the labeling of probes.

* information listed above is at the time of submission.

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