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Point-of-Care Nucleic Acid Assays

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-22-C-0026
Agency Tracking Number: A2-9158
Amount: $1,099,959.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: A20B-T022
Solicitation Number: 20.B
Timeline
Solicitation Year: 2020
Award Year: 2022
Award Start Date (Proposal Award Date): 2022-02-28
Award End Date (Contract End Date): 2024-06-27
Small Business Information
6820 Moquin Dr NW
Huntsville, AL 35806-2900
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Ketan Bhatt
 (256) 726-4908
 ketan.bhatt@cfdrc.com
Business Contact
 Tanu Singhal
Phone: (256) 361-0799
Email: contracts@cfdrc.com
Research Institution
 HudsonAlpha Institute for Biotechnology
 Flo Behn
 
601 Genome Way
Huntsville, AL 35806-2908
United States

 (256) 327-0488
 Domestic Nonprofit Research Organization
Abstract

Precision medicine promises to improve many aspects of health and healthcare, making it possible for physicians to choose the best treatment and prevention strategy for each patient. Prior research has demonstrated that genomic and transcriptomic biomarkers are useful for disease diagnosis, prognosis, and monitoring, including cancers, cardiovascular health, depression, sepsis, etc. Genetic variations and differences in gene expression levels have also been identified that affect pharmacokinetics as well as pharmacologic effects of specific drugs. Current methods for detection and quantification of these nucleic acid biomarkers requires bulky equipment and trained laboratory personnel, with turnaround times ranging from few hours to several days. A low resource cartridge is required to identify clinically relevant genes including SNPs for these applications. Proof-of-concept for such a no-power cartridge for genotyping was demonstrated in Phase I. The Phase II work will focus on further improvement of the no-power cartridge design to include additional genotyping targets as well as transition to low-volume manufacturing. The fabricated cartridges will be extensively tested and characterized against human samples. Storage and environmental testing will be carried out to evaluate cartridge performance in real-world applications.

* Information listed above is at the time of submission. *

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