IMPROVED MICROPOROUS MEMBRANES FOR MAMMALIAN CELL CULTURE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13893
Amount: $484,594.00
Phase: Phase II
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Mattek Corp.
200 Homer Ave, Ashland, MA, 01721
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mitchell Klausner
 (508) 881-6771
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MICROPOROUS MEMBRANES OFFER RESEARCHERS MANY EXPERIMENTAL ADVANTAGES OVER OTHER CELL CULTURE METHODS. IN ADDITION, CELLS CULTURED ON SUCH MEMBRANES EXHIBIT ENHANCED DIFFERENTIATION AND MANY OTHER PROPERTIES THAT CLOSELY RESEMBLE THOSE OBSERVED IN VIVO. HOWEVER, CURRENTLY THE USE OF SUCH MEMBRANES IS LIMITED TO NONANCHORAGE-DEPENDENT CELLS OR REQUIRES THAT THE MEMBRANES BE COATED WITH AN EXTRACELLULAR MATRIX (ECM), SUCH AS COLLAGEN OR POLY-LYSINE, IN ORDER TO ALLOW ANCHORAGE-DEPENDENT CELL ATTACHMENT AND GROWTH. THIS REQUIREMENT OF AN ECM NEGATES MANY OF THE POSITIVE ASPECTS OFFERED BY USING THESE MEMBRANES. THIS RESEARCH WILL INVESTIGATE THE USE OF LOW-TEMPERATURE PLASMA SURFACE MODIFICATION TO DEVELOP MICROPOROUS MEMBRANESTHAT SUPPORT ANCHORAGE-DEPENDENT, MAMMALIAN CELL CULTURE WITHOUT THE NEED FOR AN ECM COATING.

* information listed above is at the time of submission.

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