BIOCOMPATIBLE MEMBRANES FOR LONG-TERM IMPLANTATION IN THE STOMACH

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13820
Amount: $49,999.00
Phase: Phase I
Program: SBIR
Awards Year: 1990
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
200 Homer Ave, Ashland, MA, 01721
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mitchell Klausner
 (508) 881-6771
Business Contact
Phone: () -
Research Institution
N/A
Abstract
ALTHOUGH MICRODIALYSIS HAS BEEN VERY USEFUL FOR THE ACUTE MONITORING OF THE BIOCHEMICAL MECHANISMS OF THE STOMACH AND ALIMENTARY TRACT, CHRONIC STUDIES HAVE NOT BEEN AS SUCCESSFUL. HOLLOW-FIBER MEMBRANES (HFMS) IMPLANTED FOR EXTENDED PERIODS IN THE STOMACH WALLS OF LABORATORY ANIMALS HAVE CAUSED INTENSE INFLAMMATORY RESPONSES WITHIN THE HOST TISSUE, AND OCCLUSION OF THE HFMS HAS RESULTED. IN ADDITION, MICRODIALYSIS FOR GASTROINTESTINAL APPLICATIONS HAS BEEN LIMITED DUE TO LOW RECOVERIES OF HIGHER MOLECULAR-WEIGHT COMPOUNDS SUCH AS NEUROPEPTIDES. THIS RESEARCH WILL INVESTIGATE BOTH OF THESE PROBLEMS IN AN EFFORT TO MAKE MICRODIALYSIS A MORE RELIABLE AND GLOBALLY APPLICABLE TECHNIQUE. DURING PHASE I RESEARCH, HFMS WILL BE MODIFIED USING BOTH LOW-TEMPERATURE PLASMA AND WET CHEMICAL SURFACE MODIFICATIONTECHNIQUES. MODIFIED FIBERS WILL BE IMPLANTED IN THE STOMACH WALLS OF RATS, AND THE EFFECT UPON THE SURROUNDING TISSUE AS WELL AS THE DIALYSIS RECOVERIES WILL BE MONITORED. IN ADDITION, PHYSICAL MODIFICATIONS TO THE HFM WILL BE INVESTIGATED FOR IMPROVEMENT OF RECOVERIES FOR HIGHER MOLECULAR-WEIGHT SPECIES. THESE EXPERIMENTS WILL LAY THE GROUNDWORK FOR LONG-TERM PHASE II STUDIES ON GASTRIC PEPTIDES FOUND IN EXTREMELY LOW IN VIVO CONCENTRATIONS.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government