CELL CULTURE SURFACES FOR BONE RESEARCH

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16347
Agency Tracking Number:
16347
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
200 Homer Ave- Nue, Ashland, MA, 01721
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Klausner, Mitchell
Principal Investigator
(508) 881-6771
Business Contact:
1 R43 AR40797-01
() -
Research Institute:
n/a
Abstract
SURFACES FOR CELL CULTURE ARE USED IN MANY AREAS OF BONE RESEARCH. THE STUDY OF OSTEOBLAST CELL CULTURE IS CURRENTLY USED TO EXAMINE THE MOLECULAR MECHANISMS LEADING TO BONE GROWTH, MORPHOLOGY AND MINERALIZATION. UNDERSTANDING OF THESE MOLECULAR MECHANISMS GIVES INSIGHT INTO THE ORIGINS AND TREATMENT OF VARIOUS BONE DISORDERS INCLUDING GROWTH DISORDERS IN CHILDREN AND OSTEOPOROSIS IN POST MENOPAUSAL WOMEN. RECENTLY CONSIDERABLE INTEREST HAS ARISEN IN THE EFFECTS OF MECHANICAL STRAIN ON THE GROWTH OF THESE CELLS. WHILE SOME FLEXIBLE MATERIALS FOR CELL CULTURE UNDER CYCLICALLY INDUCED STRAIN HAVE BEEN PROPOSED, THE SURFACE CHEMISTRY OF MOST FLEXIBLE MATERIALS IS NOT WELL SUITED TO CELL CULTURE AND REQUIRES COATING OR OTHER SURFACE MODIFICATION PRIOR TO USE. THIS RESEARCH WILL FOCUS ON THE PLASMA SURFACE MODIFICATION OF THREE MATERIALS OF CURRENT INTEREST IN THE AREA OF OSTEOBLAST CELL CULTURE AND DETERMINE THE EFFECTS OF SURFACE TREATMENT ON THE COURSE OSTEOBLAST CELL CULTURE AND SUBSEQUENT MINERALIZATION.

* information listed above is at the time of submission.

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