Eyesafe, Multi-function Coherent Doppler Lidar for Stand-Off Bioaerosol Discrimination

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$730,000.00
Award Year:
2001
Program:
SBIR
Phase:
Phase II
Contract:
DAMD17-00-C-0029
Award Id:
55429
Agency Tracking Number:
C2-0068
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
200 Homer Ave, Ashland, MA, 01721
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
147365936
Principal Investigator:
Patrick Hayden
Senior Cell Biologist
(508) 881-6771
pjayden@mattek.com
Business Contact:
John Sheasgreen
President and CEO
(508) 881-6771
jsheasgreen@mattek.com
Research Institution:
n/a
Abstract
Chemical warfare agents such as bis-(b-chloroethyl) sulfide (HD) pose a significant threat to U.S. military and civilian populations. Exposure of skin to HD causes burn-like symptoms such as erythema, edema and severe incapacitating vesication(blistering). To combat this threat, prophylactic and/or therapeutic interventions to HD exposure are needed. Development of such interventions requires an understanding of the mechanism of action of HD. However, a major impediment to understanding ofHD-induced pathogenesis is lack of an adequate experimental model system of human skin. Since current models do not possess the appropriate attributes for HD research such as a complete basement membrane with dermal/epidermal adhesion structures, an invitro human skin model for HD-related studies is needed. The purpose of the current proposal is to develop an in vitro human skin model suitable for HD research. The model will contain human keratinocytes and/or fibroblasts and will possess allmorphological and ultrastructural features required for HD research. The model's response to HD or HD analogues will be investigated in terms of biochemical effects leading to blister formation. The model will also be utilized to gain a mechanisticunderstanding of HD-induced vesication and to investigate prophylactic and/or therapeutic interventions to HD exposure. In addition to providing a model which will greatly facilitate sulfur mustard vesication studies, this work will lead to a fullthickness skin model which will allow the study of numerous dermis-based skin phenomena such as photoaging, photodamage, wound healing and cancer progression. This improved tissue model will be useful to the cosmetic and pharmaceutical industry inirritancy and efficacy testing of their new products.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government