Eyesafe, Multi-function Coherent Doppler Lidar for Stand-Off Bioaerosol Discrimination

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: DAMD17-00-C-0029
Agency Tracking Number: C2-0068
Amount: $0.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MATTEK CORP.
200 Homer Ave, Ashland, MA, 01721
DUNS: 147365936
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Patrick Hayden
 Senior Cell Biologist
 (508) 881-6771
 pjayden@mattek.com
Business Contact
 John Sheasgreen
Title: President and CEO
Phone: (508) 881-6771
Email: jsheasgreen@mattek.com
Research Institution
N/A
Abstract
Chemical warfare agents such as bis-(b-chloroethyl) sulfide (HD) pose a significant threat to U.S. military and civilian populations. Exposure of skin to HD causes burn-like symptoms such as erythema, edema and severe incapacitating vesication(blistering). To combat this threat, prophylactic and/or therapeutic interventions to HD exposure are needed. Development of such interventions requires an understanding of the mechanism of action of HD. However, a major impediment to understanding ofHD-induced pathogenesis is lack of an adequate experimental model system of human skin. Since current models do not possess the appropriate attributes for HD research such as a complete basement membrane with dermal/epidermal adhesion structures, an invitro human skin model for HD-related studies is needed. The purpose of the current proposal is to develop an in vitro human skin model suitable for HD research. The model will contain human keratinocytes and/or fibroblasts and will possess allmorphological and ultrastructural features required for HD research. The model's response to HD or HD analogues will be investigated in terms of biochemical effects leading to blister formation. The model will also be utilized to gain a mechanisticunderstanding of HD-induced vesication and to investigate prophylactic and/or therapeutic interventions to HD exposure. In addition to providing a model which will greatly facilitate sulfur mustard vesication studies, this work will lead to a fullthickness skin model which will allow the study of numerous dermis-based skin phenomena such as photoaging, photodamage, wound healing and cancer progression. This improved tissue model will be useful to the cosmetic and pharmaceutical industry inirritancy and efficacy testing of their new products.

* information listed above is at the time of submission.

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