HIGHLY DIFFERENTIATED TISSUE CULTURE MODELS OF MELANOMA

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA090077-01A1
Agency Tracking Number: CA090077
Amount: $152,197.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MATTEK CORPORATION
MATTEK CORPORATION, 200 HOMER AVE, ASHLAND, MA, 01721
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MITCHELL KLAUSNER
 (508) 881-6771
 MKLAUSNER@MATTEK.COM
Business Contact
 JOHN SHEASGREEN
Phone: (508) 881-6771
Email: ISHEASGREEN@MATTEK.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): With the exception of lung cancer in women, the incidence of cutaneous melanoma (CM) is increasing faster than any other cancer. Current estimates are that one of every 75 individuals in the US will contract CM during his or her lifetime. The various stages of melanoma have been well described, however, to devise improved treatments allowing patients to lead longer and more productive lives, a better understanding of progression of CM is needed. The purpose of this proposal is to produce highly differentiated, tissue culture models of the various stages of CM progression. During Phase I, cell lines from the various disease states of CM will be expanded in monolayer culture and characterized. Using a serum free culture system, these cells will be incorporated into an organotypic, full thickness skin model to produce tissue reconstructs which parallel the various stages of CM in vivo. The tissues will be characterized in terms of morphology, tumor progression, and adhesion receptors. Finally, reproducibility of the tissue models will be investigated.

* information listed above is at the time of submission.

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