FLOW (CYTOMETRY)-BASED UNSCHEDULED DNA SYNTHESIS ASSAY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,998.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
54478
Agency Tracking Number:
1R43ES010881-01
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
BOX 178, 1756 WENTZ RD, SPINNERSTOWN, PA, 18968
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
EDWARD YURKOW
() -
Business Contact:
(215) 536-4110
DEGEORGE@MBRESEARCH.COM
Research Institution:
n/a
Abstract
DESCRIPTION: The development of an improved assay for genotoxicity is proposed. The assay will be based on the Unschedule DNA Synthesis assay that measures nucleotide incorporation due to repair of DNA damage. The proposal seeks to modify the assay to use non-radioactive tracers and flow cytometry. The successful completion of the proposed work will enable the applicant organization to provide an important new service to the chemical, cosmetic, consumer products and safety-testing industries. PROPOSED COMMERCIAL APPLICATION: MB Research will conduct this assay of genotoxicity (in-house) for members of the pharmaceutical, biotech, cosmetic, agrochemical, chemical and consumer products industries. Our clients are increasingly requesting rapid, reliable and inexpensive assays of genotoxicity (see letters from Brayer, Avon, and Perdue Pharma) that would be used to screen large numbers of chemicals. The results of such an assay would be used to determine which chemicals should be excluded from the product development process and which agents should move on to further tests of genotoxicity.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government