Variable compliance chamber to alter pulmonary impedance

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 1R43HL067593-01
Amount: $93,821.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
3550 W LIBERTY RD, STE 3, ANN ARBOR, MI, 48105
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: (734) 995-9089
Research Institution
DESCRIPTION (Applicant's Abstract): A variable compliance chamber (VCC) is proposed that will maintain near normal pulmonary input impedance during the treatment of pulmonary disease. Pulmonary impedance is related to the total work (steady and pulsatile) that the right heart must pump against, and it is altered (primarily in the form of decreased compliance) in pulmonary disease and in the implantation of oxygenation assist devices; this increase in work can lead to right-heart failure. A VCC will be developed that can be attached to the right-heart or combined with an implantable artificial lung to decrease the impedance seen by the right ventricle. An important application of the VCC will be to allow bridge-to-transplant or recovery treatment of patients suffering from primary and secondary pulmonary hypertension. Phase I will utilize computational techniques and bench-top experiments to allow rapid development of the VCC and thorough characterization. At the completion of phase I, a working prototype will be constructed and extensive bench-top studies will be performed to verify the ability of the VCC to decrease the pulmonary impedance spectrum, and thus decrease load on the right-heart, in the application of an oxygenation assist device. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* Information listed above is at the time of submission. *

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