Implantable Glucose Sensor with Prolonged Accuracy

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$145,049.00
Award Year:
2006
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK074243-01
Award Id:
80600
Agency Tracking Number:
DK074243
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MC3, INC., 3550 W LIBERTY RD, ANN ARBOR, MI, 48103
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MELISSA REYNOLDS
(734) 995-9089
REYNOLDS@MC3CORP.COM
Business Contact:
SEAN CHAMBERS
(734) 995-9089
schambers@mc3corp.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The goal in this study is to fabricate an intravascular glucose sensor that functions accurately for 3 days in vivo. To do this, we will develop an outer membrane that facilitates the conversion of endogenous S- nitrosothiols to nitric oxide locally at the membrane/blood interface. Since nitric oxide is released by the endothelial cells and is responsible for maintaining vascular tone and platelet inactivation, this is a natural approach that mimics the functions of the endothelium. This study involves the design of a biocompatible glucose-selective membrane, fabrication of a functional glucose sensor, and bench and animal testing to assess biocompatibility and function of the sensor. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy.

* information listed above is at the time of submission.

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