Stent Coating to Prevent Restenosis and Subacute Thrombosis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 4R44HL090087-02
Agency Tracking Number: HL090087
Amount: $876,537.00
Phase: Phase II
Program: SBIR
Awards Year: 2008
Solitcitation Year: 2008
Solitcitation Topic Code: N/A
Solitcitation Number: PHS2007-2
Small Business Information
MC3, INC., 3550 W LIBERTY RD, STE 3, ANN ARBOR, MI, 48103
Duns: 806687406
Hubzone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 (734) 995-9089
Business Contact
Phone: (734) 995-9089
Research Institution
DESCRIPTION (provided by applicant): This fast track SBIR application proposes the refinement and preclinical testing of a coating designed to inhibit restenosis and thrombosis in intravascular stents. The research plan will build on encouraging results from pilot animal studies with coated prototypes. During Phase I, the coating process will be optimized by thoroughly analyzing system variables and verifying coating properties in each step of the coating application. Preliminary biocompatibility testing will be conducted, to identify local effects of the coating on blood and tissue. Upon meeting defined process requirements and biocompatibility requirements, the project will move to Phase II, where the coating process will be implemented in an automated, controlled application apparatus. The coated stents will undergo extensive durability testing. Animal studies are planned that will investigate the activity of the stent in an isolated vessel model. Finally, the stents will be evaluated in a 28-day porcine implant model. The coating is designed as a stand-alone solution to improve stent performance; however, the coating can be combined readily with other coatings or drug-release agents.

* information listed above is at the time of submission.

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