BIOLOGICALLY STABLE HEPARIN DERIVATIVES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7336
Amount: $42,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Mccann Associates Inc
3139 South Wayne Road, Wayne, MI, 48148
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DAISY S MCCANN PHD
 (313) 721-0300
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A SERIES OF COVALENT HEPARIN-PROTEIN COMPLEXES WITH PROLONGED IN VIVO HALF-LIVES OF THE HEPARIN MOIETY AND HIGH ANTICOAGULANT ACTIVITY WILL BE DEVELOPED. A SERIES OF PROTEINS COVERING A BROAD RANGE OF MOLECULAR WEIGHTS AND ISOELECTRIC POINTS WILL BE CHOSEN FOR THESE CONJUGATES. VARIOUS CONJUGATION TECHNIQUES WILL BE INVESTIGATED TO DETERMINE THE METHOD THAT WILL RETAIN THE BEST ANTICOAGULANT ACTIVITY FOR THE HEPARIN. THE RELATIVE ABILITY OF THE COVALENT PROTEIN-HEPARIN COMPLEXES TO CATALYTICALLY ACCELERATE THE INHIBITION OF THROMBIN AND FACTOR X WILL BE MEASURED BY STOPPED-FLOW FLUORIMETRY. PROLONGATION OF ACTIVATED PARTIAL THROMBOPLASTIN TIME WILL BE USED TO EVALUATE POTENTIAL IN VIVO ANTICOAGULANT ACTIVITY. ULTIMATELY, BUT NOT AS PART OF THE PHASE I STUDIES, HALF-LIVES AND EFFICACY WILL BE DETERMINED IN CONTROLLED CLINICAL STUDIES.

* information listed above is at the time of submission.

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