BIOLOGICALLY STABLE HEPARIN DERIVATIVES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$42,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7336
Agency Tracking Number:
7336
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3139 South Wayne Road, Wayne, MI, 48148
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAISY S MCCANN PHD
(313) 721-0300
Business Contact:
() -
Research Institute:
n/a
Abstract
A SERIES OF COVALENT HEPARIN-PROTEIN COMPLEXES WITH PROLONGED IN VIVO HALF-LIVES OF THE HEPARIN MOIETY AND HIGH ANTICOAGULANT ACTIVITY WILL BE DEVELOPED. A SERIES OF PROTEINS COVERING A BROAD RANGE OF MOLECULAR WEIGHTS AND ISOELECTRIC POINTS WILL BE CHOSEN FOR THESE CONJUGATES. VARIOUS CONJUGATION TECHNIQUES WILL BE INVESTIGATED TO DETERMINE THE METHOD THAT WILL RETAIN THE BEST ANTICOAGULANT ACTIVITY FOR THE HEPARIN. THE RELATIVE ABILITY OF THE COVALENT PROTEIN-HEPARIN COMPLEXES TO CATALYTICALLY ACCELERATE THE INHIBITION OF THROMBIN AND FACTOR X WILL BE MEASURED BY STOPPED-FLOW FLUORIMETRY. PROLONGATION OF ACTIVATED PARTIAL THROMBOPLASTIN TIME WILL BE USED TO EVALUATE POTENTIAL IN VIVO ANTICOAGULANT ACTIVITY. ULTIMATELY, BUT NOT AS PART OF THE PHASE I STUDIES, HALF-LIVES AND EFFICACY WILL BE DETERMINED IN CONTROLLED CLINICAL STUDIES.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government