NOVEL DENSE HOLLOW FIBER FOR BLOOD-GAS EXCHANGE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$160,699.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL068375-01A1
Agency Tracking Number:
HL068375
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
MEDARRAY, INC.
MEDARRAY, INC., 1610 HARBAL DR, ANN ARBOR, MI, 48105
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JEAN MONTOYA
(734) 761-3889
MONTOYA@MEDARRAY.COM
Business Contact:
JEAN MONTOYA
(734) 761-3889
MAIN@MEDARRAY.COM
Research Institution:
n/a
Abstract
We have devised a technique that will greatly simplify and make cost effective the fabrication of dense silicone fibers for use in gas exchange applications including long-term extracorporeal life support, implantable artificial lung, and other cardiorespiratory procedures. The technique allows for producing, non-porous, high performing, and economically attractive compact gas exchange devices, analogous to their microporous membrane hollow fibers (MMHF) counterparts. Devices incorporating MMHF have become popular mainly because of enhanced gas exchange due to the convective mixing induced by blood flowing over thousands of tiny hollow fibers. This property allows for designing highly efficient gas exchange devices in relatively compact volumes. Yet MMHF suffer from fowling, and plasma leakage when they are used for extended periods of time, and from propensity to gas embolization when the gas side pressure exceeds the blood side pressure. Thus incorporating the compactness and effectiveness of hollow fibers configuration with the ability of solid silicone membranes to withstanding plasma leakage and gas embolization are desirable properties in a membrane designed blood oxygenation. In Phase 1 we propose to further develop the fabrication technique and to evaluate the gas exchange and hemodynamic performance of the dense hollow fibers incorporated in prototype as exchange devices.

* information listed above is at the time of submission.

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