Quantitative Assessment of Microembolic Involvement

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HL48420-1A3,
Agency Tracking Number: 25137
Amount: $78,565.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Medical Physics, Inc.
825 North 300 West, Ste 420, Salt Lake City, UT, 84103
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Michael Criddle
 (801) 532-0221
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will establish the feasibility for applying a new and noninvasive method to the developmentof a practical instrument for sensitive and quantitative detection of microembolic involvement in humanlungs. Because present methods for detection of pulmonary emboli utilize imaging techniques, the sizeof emboli detectable by these methods are limited by the inherent spacial resolution of x-ray and gammacameras. Microemboli (obstruction of the microcirculation) are therefore too small to be detected bystandard methods. Since microemboli are not detectable, there is no direct evidence that microembolicinvolvement is of clinical significance. However, microembolic involvement has been shown to be acause in Adult Respiratory Distress Syndrome (ARDS), a disease having a high mortality (over 50%) inhumans. Microembolic involvement in other trauma associated conditions, including surgery, is alsospeculative. Phase I would address validation of the principle of the new method in experimentalanimals. The economic goal of Phase II would be to test the likelihood of microembolic detectionbecoming standard medical practice. Accomplishment of this goal involves a combination of technicaldevelopment and scientific studies. Given a successful Phase I, Phase II would 1) develop a practicalinstrument for human studies, and 2) perform clinical research studies designed to verify thespeculations of microembolic involvement in ARDS and other trauma associated conditions.

* information listed above is at the time of submission.

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