Lung Metabolic Monitor
Department of Health and Human Services
1 R43 HL51673-01A3,
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Medical Physics, Inc.
825 North 300 West, Suite 420, Salt Lake City, UT, 84103
Socially and Economically Disadvantaged:
AbstractThe major rationale for the development of a lung metabolic monitor (LMM) is the need for a markerendothelial injury and lung inflammation such as that involved in Adult Respiratory Distress Syndromused for lung metabolic fraction (LMF) measurement involve the measurements of whole-body O2 consumpand O2 consumption by the Fick principle (V-O2Fick). The approach is based on the premise that V-O2FV- O2L, whereas the airway measurement represents whole-body V-O2 which includes the lung. The problclinical researchers is that the combined uncertainties of the independent V-O2 and V- O2Fick measurthe ICU environment, are of nearly the same magnitude as the LMF values to be monitored. This is dueinherent differences in the thermodilution and Fick methods and the necessity of measuring V-O2 undeconditions. Our method retains the principle of determining LMF described above. However, two majorpresent method are proposed: l) The non-Fick Q measurement is replaced with a non-metabolic gas Fickprinciples with the V-O2Fick method; and 2) O2 is replaced by CO2 as the lung metabolism indicator imetabolic and non metabolic gas uptake (production) measurement techniques and to eliminate the needgas flows or volumes. LMF accuracy is thereby reduced to the technical problem of in vitro measuremeconcentration measurements in the blood and gas phases. However, there is presently no blood contentthis task. To meet this need, this group has utilized engineering concepts of the 1990's to re-enginapparatus, developed in the 1920's. The new design meets the accuracy requirements for an LMM; in whindependent,of operator skill. The goal of the Phase I is to establish that the method has the accurclinical research needs of an LMM.
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