CD4 Based Therapeutic Vaccine for HIV

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI36029-01A1,
Agency Tracking Number: 29086
Amount: $99,983.00
Phase: Phase I
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
35 West Watkins Mill Road, Gaithersburg, MD, 20878
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Cassatt
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
An effective therapeutic vaccine for HIV should be capable of reducing viral load and spread of infprevent the onset of AIDS. In an SIV-rhesus macaque model, immunization with a recombinant, solubleCD4 molecule (rsCD4) induced an anti-CD4 response that reduced viral load and rendered PBLs from theanimals resistant to infection with SIV. This anti-viral activity was found in the IgG fraction of tI clinical study HIV-infected individuals immunized with human rsCD4 in IFA developed an anti-CD4 reachieved were insufficient to prevent spread of HIV. These results suggest that B cell tolerance toovercome. This application will focus on developing strategies for enhancing immune responses to rsCmodel tolerant to human CD4. In particular, a series of vaccines composed of vaccines composed of rhprotein conjugates of CD4-derived peptide conjugates formulated in different adjuvants will be evaluenhance T helper and B cell responses in a mouse model expressing a human CD4 transgene. This studyselection of a more immunogenic rsCD4 formulation for clinical study.

* Information listed above is at the time of submission. *

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