CD4 Based Therapeutic Vaccine for HIV
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35 West Watkins Mill Road, Gaithersburg, MD, 20878
AbstractAn effective therapeutic vaccine for HIV should be capable of reducing viral load and spread of infprevent the onset of AIDS. In an SIV-rhesus macaque model, immunization with a recombinant, solubleCD4 molecule (rsCD4) induced an anti-CD4 response that reduced viral load and rendered PBLs from theanimals resistant to infection with SIV. This anti-viral activity was found in the IgG fraction of tI clinical study HIV-infected individuals immunized with human rsCD4 in IFA developed an anti-CD4 reachieved were insufficient to prevent spread of HIV. These results suggest that B cell tolerance toovercome. This application will focus on developing strategies for enhancing immune responses to rsCmodel tolerant to human CD4. In particular, a series of vaccines composed of vaccines composed of rhprotein conjugates of CD4-derived peptide conjugates formulated in different adjuvants will be evaluenhance T helper and B cell responses in a mouse model expressing a human CD4 transgene. This studyselection of a more immunogenic rsCD4 formulation for clinical study.
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