Lyme Disease Vaccine Using Gonococcal Blebs

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AI37479-01,
Agency Tracking Number:
29113
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Medimmune, Inc.
35 W Watkins Mill Road, Gaithersburg, MD, 20878
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 John Cairns
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
The investigators will develop a system in which OspA, an antigen known to induce protective immuneagainst Borrelia burgdorferi, the causative agent of Lyme Disease, is cloned and exported to the outNeisseria gonorrhea, a bacterium that naturally turns over its outer membrane into easily isolated iantigen will be expressed in blebs either as a complete protein or by fusion to another gonococcal cLocalization of the antigen in blebs will be characterized and the blebs used in animal studies to dimmunogenicity of the construct as well as its potential ability to elicit protective immune respons

* information listed above is at the time of submission.

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