Lyme Disease Vaccine Using Gonococcal Blebs

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 AI37479-01,
Award Id:
29113
Agency Tracking Number:
29113
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
35 W Watkins Mill Road, Gaithersburg, MD, 20878
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
John Cairns
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
The investigators will develop a system in which OspA, an antigen known to induce protective immuneagainst Borrelia burgdorferi, the causative agent of Lyme Disease, is cloned and exported to the outNeisseria gonorrhea, a bacterium that naturally turns over its outer membrane into easily isolated iantigen will be expressed in blebs either as a complete protein or by fusion to another gonococcal cLocalization of the antigen in blebs will be characterized and the blebs used in animal studies to dimmunogenicity of the construct as well as its potential ability to elicit protective immune respons

* information listed above is at the time of submission.

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