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Time-Resolved Imaging of Cervical Cancer Acetowhitening

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R44CA091618-01
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
45 HARTWELL AVE
LEXINGTON, MA 02421
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 HOWARD KAUFMAN
 () -
Business Contact
Phone: (781) 372-2410
Email: KRICCI@MEDISPECTRA.COM
Research Institution
N/A
Abstract

DESCRIPTION (Provided by Applicant): This study will examine the use of timed
image acquisition, wavelength filtered light and ace to whitening kinetics to
improve the accuracy of colposcopy for the routine clinical diagnosis of
cervical cancer. A colposcopy workstation will be built with enhanced software
and wavelength filtered light capability to collect necessary patient data.

A cohort of 25 patients with high grade Cervical Intraepitheliel Neoplasia (C/N
II/III will be imaged with the modified I workstation to quantify how these
image enhancements improve the predictive value of colposcopy. The
time-dependent and spectral data will be used to improve the accuracy of
colposcopy in the discrimination of high grade lesions from other conditions
including low grade lesions (C/NI) and normal tissue.

A time-sequenced series of images will be collected after the uniform and timed
application of 5 percent acetic acid onto the cervix. Images will be processed
to find predictive markers such as (1) lifetime and intensity of acetowhitening and
resulting temporal decay curves, and (2) spectral changes in reflectance due to
acetowhitening. Techniques will be improved for the processing and analysis of
temporal curves to enhance their predictive value.
PROPOSED COMMERCIAL APPLICATION:
Completion of this Phase I program will lay the groundwork for significantly improved digital
colposcopic instrumentation. The timed spectral images of cervical acetowhitening will
improve the quality of clinical treatment while reducing costs. As with any new technology,
market commercialization will depend on the willingness of physicians to accept the new technology. The device developed in this application, however, is similar to existing
colposcopes, and the barrier to acceptance should be less as users in the OB/Gyn
community are familiar with this equipment. The device will allow for improved accuracy
in the mapping and grading of cervical cancer.

* Information listed above is at the time of submission. *

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