THE OBJECTIVE OF THIS WORK IS DEVELOPMENT OF A LASER DOPPLER CATHETER SYSTEM (LDCS) FOR THE INVASIVE ASSESSMENT OF VASCULAR FLOW.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3247
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Medpacific Corpon
6701 Sixth Avenue South, Seattle, WA, 98108
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GUY F. BOGAR
 PRINCIPAL INVESTIGATOR
 (206) 763-9177
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVE OF THIS WORK IS DEVELOPMENT OF A LASER DOPPLER CATHETER SYSTEM (LDCS) FOR THE INVASIVE ASSESSMENT OF VASCULAR FLOW. CURRENT NONINVASIVE ASSESSMENTS OF CORONARY FLOW (RADIONUCLIDE IMAGING AND RADIOACTIVE MICROSPHERE DISTRIBUTION) ARE COMPLEX AND EXPENSIVE, WHILE LACKING RESOLUTION AND CLINICAL UTILITY. LDCS WOULD ALLOW ABSOLUTE SUBSELECTIVE ASSESSMENT OF CORONARY FLOW AND STENOSIS IN INDIVIDUAL ARTERIES, AND MEASUREMENTS COULD BE OBTAINED DURING DIAGNOSTIC CARDIAC CATHETERIZATION USING STANDARD TECHNIQUES. THE EXPECTED RESULTS OF THE PHASE I EFFORT WILL BE TO CONSTRUCT A PROTOTYPE CATHETER SYSTEM CAPABLE OF MEASURING VELOCITIES UP TO 2 METERS/SECOND. THE SYSTEM WILL BE CALIBRATED IN A HYDRAULIC TEST LOOP, AND WILL SIGNIFICANCE OF THE WORK: THE LDCS WOULD HAVE WIDESPREAD APPLICATION IN THE PHYSIOLOGIC ASSESSMENT OF CORONARY ARTERY DISEASE. CORONARY ANGIOGRAPHY YIELDS NO PHYSIOLOGIC INFORMATION AND OFTEN UNDERESTIMATES INTERMEDIATE (25% TO 60%) STENOSIS. LASER DOPPLER TECHNIQUES, BY SENSING THE HIGH VELOCITY FLOW REGION IN THE STENOTIC LUMEN, COULD AIM HIGH POWER THERAPEUTIC LASER CATHETERS. PERFORATION RISKS WOULD BE MINIMIZED AND TREATMENT EFFECTS COULD BE MONITORED.

* information listed above is at the time of submission.

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